In cystic fibrosis (CF), defective biogenesis and activity of the cystic fibrosis transmembrane conductance regulator (CFTR) leads to airway dehydration and impaired mucociliary clearance, resulting in chronic airway infection and inflammation.The most common CFTR mutation, F508del, results in a processing defect in which the protein is retained in
A key issue in the spatial and temporal analysis of residential burglary is the choice of scale: spatial patterns might differ appreciably for different time periods and vary across geographic units of analysis.Based on point pattern analysis of burglary incidents in Columbus, Ohio during a 9-year period, this study develops an empirical framework
We study the dependence of salinity on temperature in two by two degrees latitude-longitude boxes, for surface and upper-thermocline waters of the eastern North Atlantic subtropical gyre.The initial data set, from historical databases as well as from recent hydrographic cruises in the region, is carefully scrutinized to Audio Turntable Cartridge Wi
Background/Aims Endoscopic submucosal dissection (ESD) is currently considered the first-line treatment for the eradication of superficial neoplasms of the esophagus in Eastern countries.However, in the West, particularly in Latin America, the experience with esophageal ESD is still limited because of the high technical complexity required for its